The InfraRed Server Suite (IRSS) plugin expands support to 28+ more remotes, from iMON to Wii and MacMini. With IRSS you can create layers for your remote so one key can perform many functions.
IRSS offers a suite of applications to expand the functions you can perform with your remote.
Generic Keyboard/Remote Input Plugin enables you to use a "simpler" MPC or other remote, that sends key strokes
You might also use the Message Plugin in combination with other software, like EventGhost or Girder. Let EventGhost or similar software, send messages (read: keypresses or actions), to MediaPortal. So, when your remote is supported by EventGhost and you want to have complete control on what happens with your button presses, use this.
MediaPortal supports the following remotes 'out of the box'
Customizing Remote Mappings
For details and configuration options, see the individual remote.